Compare the three B12 products head-to-head — the sublingual methyl form, the studied standard softgel, and the vegan-certified tablet. In B12's comparison, the honest conclusion is unusual: the differences that matter are dose, consistency, and label honesty — not form, brand, or route.



| Metric | 🏆Jarrow Formulas Methyl-B12 (1000 mcg) Jarrow Formulas | Nature Made Vitamin B12 1000 mcg Nature Made | DEVA Vegan Vitamin B12 DEVA |
|---|---|---|---|
| Delivery Form | Sublingual Lozenge | Softgel | Tablet |
| Strength | 1000 mcg | 1000 mcg | 1000 mcg |
| Servings / Container | 100 | 150 | 90 |
| Retail Price | $14.95 | $8.99 | $9.99 |
| Cost / Serving | $0.15 | $0.06BEST 💰 | $0.11 |
| Overall Score | 86/100 | 87/100 | 84/100 |
| 3rd-Party Testing | None | USP | None |
| Vegan Friendly | ✓ Yes | — No | ✓ Yes |
The 1,000 mcg daily dose is the mechanism: ~1% passive absorption delivers 10 mcg — 4× the requirement — even with the entire cascade broken. Smaller doses depend on the cascade working; the 1,000 mcg dose doesn't care.
Cyanocobalamin and methylcobalamin both correct deficiency in every head-to-head comparison. The form debate is marketing; the dose and the daily habit are the pharmacology.
Sublingual absorption's advantage over swallowed is modest-to-theoretical — the lozenge's real benefits are taste and ritual. The 1,000 mcg swallowed works identically.
The liver's 3–5 year buffer means the unfortified vegan's deficiency is invisible for years — and the daily 1,000 mcg tablet (or fortified foods) makes the question moot for pennies. The one supplement every dietetic body mandates.
IM B12 remains the right answer for severe deficiency with neurological symptoms, or where oral fails — the severity decides, the prescriber orders. The B12 IV-bar ritual is the placebo economy in a bar chair.
Serum B12 near the low end is ambiguous — methylmalonic acid (MMA) rises early and specifically in true deficiency. The two-test combination converts the borderline into a diagnosis.